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The GORE Flow Reversal System is a unique neuroprotection system that operates on the principle of reversing the flow of blood at the treatment site. With flow reversal established, the GORE Flow Reversal System continuously directs both macro and micro emboli away from the brain, minimizing the risk of emboli reaching the brain during critical stages of carotid artery stenting (CAS). Because the system is positioned proximal to the target lesion, protection is established before interaction with the target lesion occurs, minimizing the risk of emboli while establishing protection.