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Investigation of the Hemodynamic Effect of StentWires on Renal Arteries in Patients with Abdominal Aortic Aneurysms Treated with Suprarenal Stent-Grafts


Zhonghua Sun and Thanapong Chaichana
Journal: Cardiovasc Intervent Radiol (2009) 32:647-657


Purpose: This study was designed to investigate the hemodynamic effect of stent struts (wires) on renal arteries in patients with abdominal aortic aneurysms (AAAs) treated with suprarenal stent-grafts. A computer simulation based on real patient data was used to investigate whether there is any significant interference of suprarenal stent wires with renal blood flow, based on variable stent wire crossing and different wire thicknesses.

Data from pre- and post-implant CT angiographic images of two sample patients that underwent endovascular repair of AAA with the Cook Zenith® stent-graft were collected and used to generate eight juxtarenal models featuring four configurations of suprarenal fixation stent wires crossing the renal artery ostia. The four wire crossing configurations can be seen in Figure 1.

Using a two-way fluid structure interaction analysis, the blood flow pattern, flow velocity, wall pressure, and wall shear stress at the renal arteries pre- and post-implant were analyzed and compared. The stent wire thickness was modeled with a diameter of 0.4, 1.0, and 2.0 mm. The 0.4 mm diameter is comparable with the suprarenal struts of the Cook ZENITH® and Medtronic TALENT stent-graft. The results of this study indicate that flow velocity to the renal artery was mainly affected by the thickness of stent wires and the configuration of stent wires crossing the renal ostium. According to the authors, "The flow velocity was reduced by 20 - 30% in most of the situations when the stent wire thickness increased to 1.0 and 2.0 mm. Of the four types of configuration, the single wire crossing centrally resulted in the highest reduction of flow velocity, ranging from 21% to 28.9% among three different wire thicknesses." Additionally, the pre-stent-grafting laminar flow to the renal arteries was observed to be turbulent after wires were placed across the renal ostia.
Patient Artery Wire Configuration Percent change in flow velocity calculated
with differentwire thickness (m / s)
      0.4 mm 1.0 mm 2.0 mm
1 LRA Single wire
crossing peripherally
0.5% -23.7% -18.0%
  RRA Double wire
crossing peripherally
-1.8% -13.0% -19.2%
2 LRA V-Shaped wire
crossing
-5.0% -5.7% -12.2%
  RRA Single wire
crossing centrally
-21.1% -21.1% -28.9%


Previous studies have shown that the morphology of renal ostia have changed due to the presence of suprarenal stent wire crossing, although renal function was unaffected:

This study is consistent with other studies which concluded that blood flow reduction
was independent of renal ostium and stent wire diameters.

However, this study showed that the configuration of the wire crossing, as well as stent wire
thickness, determine renal blood flow. In fact, a single wire crossing the renal ostium centrally
results in more than a 20% reduction in blood velocity.

Multiple diameters of suprarenal stent wires were simulated in this study because it is possible for organic, biological material from a patient's blood to adhere to a wire. This was confirmed by previous work showing that small pieces of materials were deposited onto suprarenal stent wires, resulting in an increase in cross-sectional area of the stent wire1, which effectively reduces the cross-sectional area of the renal ostia2. Additionally, the decreased cross-sectional area of the renal ostium is significantly higher in the presence of multiple thicker stent wires (wire diameter ranging from 0.98 to 1.3 mm), resulting in a reduction between 26% and 46.7%3. This study demonstrated that the wall shear stress at the renal arteries was reduced significantly in the presence of stent wires across the renal ostium, especially with larger wire diameters. The authors suggest that this should raise clinical concern since low wall shear stress is associated with neointimal hyperplasia in bypass graft or stent4. Conceptually, the formation of neointimal hyperplasia on suprarenal stent wires resulting from low shear stress could reduce the crosssectional area of the renal ostium, subsequently reducing renal artery blood flow.

A comprehensive review of the published literature showed that patients treated for abdominal aortic aneurysms with the GORE EXCLUDER® AAA Endoprosthesis had very low rates of renal impairment post-implant. Collectively, 868 patients were included in this analysis, and the average rate of renal impairment was 0.69%5-16. These data, in conjunction with the information provided in this summary, suggest that the infrarenal active fixation of the GORE EXCLUDER® Device provides unparalleled clinical data with a low potential adverse impact on renal function.

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