Results from an Italian multicentric registry comparing heparin-bonded ePTFE graft and autologous saphenous vein in below-knee popliteal bypasses

Dorigo et al. 20121

Department of Vascular Surgery, University of Florence, Florence, Italy

Primary patency of GORE® PROPATEN® Vascular Graft

N=414
4 years 45%

 

 

N=142
4 years 39%

 

 

Patient characteristics

Characteristic N %
Arterial hypertension 482 87%
Diabetes 253 46%
Chronic renal failure 82 15%
History of smoking 403 72%
Hyperlipemia 330 59%
Coronary artery disease 251 45%
BK fem-pop 414 75%
Infrapopliteal 142 26%
TP trunk 69 13%
Anterior tibial 27 5%
Posterior tibial 35 6%
Peroneal 11 2%

Study details

  • Retrospective, non-randomized, multi-center analysis
  • Comparing GORE® PROPATEN® Vascular Graft and autologous saphenous vein
  • There was no statistically significant difference in secondary patency or limb salvage between GORE® PROPATEN® Vascular Graft and autologous saphenous vein

…we had a 13% increase in secondary patency rates in ePTFE group, whereas the corresponding figure was only 6% in patients with occluded vein, thus confirming both the possibility of effectively treating occluded heparin-bonded grafts and the difficulty of dealing with occluded vein bypasses. — W. Dorigo

In patients with critical limb ischemia, the rates both of amputations at 4 years and of amputation-free survival were not different between autologous vein and heparin-bonded ePTFE…and this is an encouraging result, considering that limb salvage probably represents the main outcome in all these critical patients. — W. Dorigo

1. Dorigo W, Raffaele P, Piffaretti G.  Results from an Italian multicentric registry comparing heparin-bonded ePTFE graft and autologous saphenous vein in below-knee femoro-popliteal bypasses.  Journal of Cardiovascular Surgery 2012;53(2):187-193.

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